Dry cell considers to regard life science as one of the most popular research domains, be in our country in recent years very active. According to statistic, the paper shows trend of grow in quantity of year after year related the dry cell that our country publishs every year in SCI core periodical, all exceeded 2000 with the paper number that published 2007 2006. Retrieve the paper measure that our country dry cell studies to be published in SCI core periodical since 2000 and circumstance of its factor of influence (number of SCI factor of influence is pressed announced several computation) 2007, discover the number of paper factor of influence that at present our country publishs in dry cell domain exceeds 35 have 11 research group, among them factor of influence of before total digital line 4 for institute of hematology of Chinese academy of medical sciences institute of medicine of foundation of academy of medical sciences of Deng Hongkui of academy of sciences of life of Zhao Chunhua of institute of medicine of foundation of academy of medical sciences of Han Zhongchao, China, Beijing University, military affairs wool is peaceful, total factor of influence is achieved respectively 157.253, 95.281, 93.37, 75.111, have some of sheet among them piece paper factor of influence is achieved 10.896.
A few experts think, our country scholar is capable to be in the positive result of dry cell research that international high level publishs them on scientific periodical, make certain field get military thing, for our country dry cell considers to lay better foundation.
What want the introduction today is to come from become divided of cell of academy of sciences of Beijing University life and director of dry cell lab, deng Hongkui, was 2000 the learned man of the Yangtse River that introduces from the United States. After going back to the motherland 2000, deng Hongkui produces the knowledge that he accumulates in abroad and experience adequately, overcome difficulty to establish a laboratory, a few years short made remarkable success.
A few days ago, deng Hongkui is in Cell child milepost of an IPS technology was published on print CellStemCell type article, this was representing the IPS technology of our country to march toward new height again. (detailed circumstance clicks please: Achievement of milepost type of IPS of hair of Beijing University CellStemCell)
Become divided of Beijing University cell and cellular project lab were built to basically be engaged in project of cellular become divided, cell and its medicine using research after going back to the motherland in April 2001.
At present the lab already built efficient turn gene and gene are knocked except technical platform, set quite the room of education of embryonic dry cell of dimensions, microscopical operation lab and the small rat that accord with international standard are raised and progenitive system. Below appropriate mechanism and condition of moving system safeguard, these research develop productivity of reality of conditional hopeful translate into.
The lab does a cell to cure studies diabeticly and build puppy of virus of AIDS virus and third hepatitis to affect a model in embryo of choose and employ persons two big fields obtained major breakthrough and result. In embryo of choose and employ persons dry cell treats diabetic research in, successful and revulsive embryonic dry cell of the person the become divided to cell of functional sex β , this one breakthrough offerred a possible new approach for diabetic cellular cure, admit generally on international and be paid close attention to extensively, international PCT patent filed on the base that filing domestic patent in April 2005. At present the lab does a cell in embryo directional and revulsive become divided secretes a cell for insulin this one research just is in international up banner level, the research that continues to develop this field deep is diabetic remedial open up finally likely a brand-new remedial way.
Building puppy of virus of AIDS virus and third hepatitis to affect model domain, the lab obtained high person source to change immune system and person source to turn the small mouse model of hepatic system. This model can use the vaccine of virus of Yu Aizi disease and third hepatitis and medicaments development, reduce cost of research and development; Still can use at diseases of a lot of human blood sex and hepatic disease to send the research that interpretation of the cause manages, and the infection model that compose builds a lot of other to contract sexual disease, use at clinical before medicaments is chosen, the preparation that vaccinal evaluation and person source influence Chan Kelong antibody, will form own intellectual property likely, and hopeful obtains tremendous society and economic benefits. The puppy infection model that this project place develops reachs puppy of third hepatitis virus to affected a model to obtain Biermeilindagaicijijinhui to aid financially in AIDS virus.
In addition, during SARS, lab also made the job that has certain effect, relevant article is cited nearly 130 times.
Dr. Deng Hongkui
Beijing University the Yangtse River hires a professor especially
Study and working resume
2001- now, beijing University the Yangtse River hires a professor especially
1998-2001, american hemp saves ViacellInc. Company, molecular biology director
1997-1998, american hemp saves AntigenExpress, inc. Company. Immune biology fastens department head
1995-1997, skirballInstitute of center of medicine of university of American new York, postdoctoral research
Professor Deng Hongkui obtained doctor's degree of American UCLA immunology 1995, hind pursue postdoctoral research at lab of academician of DANLITTERMAN of new York university, the virus that ever discovered HIV suffers body CCR5 (NATURE1996, 1997, the article cites more than times 2000)
1989-1995, american UCLA university, doctoral graduate student, doctor's degree
1984-1987, the 2nd medical university of Shanghai immune institute, master graduate student, master's degree
1980-1984, wuhan university biology is, baccalaureate
Scientific research domain is described
Main interest depends on this lab:
1. body cell weighs process designing
2. person embryo does a cell directional become divided
3. builds disease animal model through the method that decorates hereditarily
ResearchFields:
1.Nuclearreprogramming
2.Directeddifferentiationofhumanembryonicstemcells
3.Animalmodelsfordiseaseresearch
Representative primitive paper
SelectedOriginalPapers:
1.ZhangP, liJ, wangC, tanZ, liuT, chenL, yongJ, jiangW, sunX, dingM, dengH, 2008.Short-termBMP-4treatmentinitiatesmesoderminductioninhumanembryonicstemcells.Blood111(4):1933-41.2.JiangW, baiZ, zhangD, shiY, yongJ, chenS, dingM, dengH, 2008.DifferentiationofMouseNuclearTransferEmbryonicStemCellsintoFunctionalPancreaticBetaCells.Diabetologiainpress3.WangC, faloonP, tanZ, lvY.ZhangP, dengH, xiongJ, 2007.MouseLycatControlstheDevelopmentofHematopoieticandEndothelialLineagesduringinvitroESCellDifferentiation.Blood110(10):3601-9.4.CaiJ, zhaoY, yeF, liuY, songZhi, qinH, mengS, chenY, zhouR, songX, guoY, dingM, dengH, 2007.Directeddifferentiationofhumanembryonicstemcellsintofunctionalhepaticcells.Hepatology45(5):1229-1239.5.QinH, yuT, qingT, liuY, zhaoY, caiJ, liJ, songZ, quX, zhouP, wuJ, dingM, dengH, 2007.Regulationofapoptosisanddifferentiationbyp53inhumanembryonicstemcells.JBiolChem282(8):5842-52.5.QinH, yuT, qingT, liuY, zhaoY, caiJ, liJ, songZ, quX, zhouP, wuJ, dingM, dengH, 2007.Regulationofapoptosisanddifferentiationbyp53inhumanembryonicstemcells.JBiolChem282(8):5842-52.6.ZhengA, yuanF, liY, zhuF, houP, liJ, songX, dingM, dengH, 2007.Claudin-6andClaudin-9FunctionasAdditionalco-ReceptorsforHepatitisCVirus.JVirol81(22):12465-71.7.QingT, liuH, weiW, yeX, shenW, zhangD, songZ, yangW, dingM, dengH, 2007.Matureoocytesderivedfrompurifiedmousefetalgermcells.HumanReproduction134(2):223-31.8.RenL, gaoG, zhaoD, dingM, luoJ, dengH, 2007.DevelopmentalstagerelatedpatternsofcodonusageandgenomicGCcontent:sEarchingforevolutionaryfingerprintbymodelsofstemcelldifferentiation.GenomeBiol12;8(3):R35.9.ShiY, houL, tangF, jiangW, wangP, dingM, dengH, 2005.InducingEmbryonicStemCellstoDifferentiateintoPancreaticBetaCellsbyaNovelThree-StepApproachwithActivinAandAll-TransRetinoicAcid.StemCells23(5):656-62.52.10.DengH, unutmazD, kewalramaniV, littmanD, 1997.Expressioncloningofnovelcoreceptorsutilizedbythesimionandhumanimmunodeficencyviruses. .Nature388:296-300.11.DengH, liuR, ellmeierW, choeS, untmazD, burkhartM, marazioP, marmonS, suttonR. , hillC, davisC, peiperS, schallT, littmanD, landauN, 1996.Identificationofamajorco-receptorforprimaryisolatesHIV-1.Nature381:661-666. (Http://www.ebiotrade.com/ )
