8 years list of fund of prominent young person gives heat, biology knows the academic result that introduces winner of life science domain for you, the scientific research that pays close attention to their near future makes progress. Apply one fair parted to send an article each in Cell and Nature 2008, detailed circumstance sees below:
Apply one fair, ancestral home Yunnan, was born in Zhengzhou on May 5, 1967, the middle school is read visit experimental middle school at Henan.
September 1985 ~1989 year in August, tsinghua university, biologic bachelor, graduate one year ahead of schedule
In September 1990 ~1995 year in April, the United States makes an appointment with university of writing suddenly Pu Jinsi (JohnsHopkinsUniversity) , doctor's degree of molecular biology physics
In January 1996 ~1998 year in January, new York Silongkaitelin cancer research center (laboratory of MemorialSloan-KetteringCancerCenter) structure biology is postdoctoral;
In Feburary 1998 ~2001 year in October, princeton university (PrincetonUniversity) element biology is, assistant professor
In October 2001 ~2003 year in March, princeton university is taught personally eventually, the associate professor is held
March 2003 ~2007 year in March, princeton university is taught personally eventually, orthodoxy is awarded hold
March 2007 ~11 month, biology of Princeton college member fastens Warner-Lambert/Parke-Davis to teach in November 2007 ~ up to now, assistant dean of science of Tsinghua university life and medical academy, the professor obtained Guo Jiajie to give young fund 2008Be in Princeton university, he uses physics of structural biology, biology and biochemical method, research cell wither dies and the cent pickaback plane of cancer happening is made. Up to now, he publishs paper in magazine of international authority science more than 100, be in as newsletter writer among them according to not complete count " cell " publish 14, " natural " publish 8, " science " publish 4. These jobs announced systematically wither of the cell in mammalian, drosophila and wireworm dies the molecular mechanism of access, already had a certain number of research achievement patent application, use at treating the medicaments research and development of cancer. Because die to conduct the excellent job that waits for a domain with TGF- signal in cellular wither, he was learned to award scientist of youth of E Wenxi case prize by international protein 2003, it is this award since establishing scholar of the first foreign citizen of Chinese origin that obtains this special honour. 2005, be elected as chairman of Chinese biologist association. Introduce according to applying homepage of lab of staff room of biology of member of fair Princeton college (Http://www.princeton.edu/~ygshi/home.htm)Wither of ShiLab attention cell dies mechanism. So far, already successful ground is analytic 20 control are mammalian, black abdomen drosophila, the albumen crystal structure that wither of cell of wireworm of beautiful concealed lever dies. Undertake study on the biologic signal access that undertakes on this foundation cellular wither dies. Study way: The signal access that the wither of cell of signal access drosophila that the wither of setting mammal cell that cellular wither dies dies dies is beautiful the cellular wither of wireworm dies access of signal of TGF-beta of albumen of signal access SmadThe 2008 article that biology reports applies one fair " Cell " child print discovers new mechanism Http://www.ebiotrade.com/newsf/2008-10/2008109155749.htmCell: Tsinghua is applied one fair analytic and methylic change Http://www.ebiotrade.com/newsf/2008-9/200895164727.htm of enzymatic crystal structure to apply one fair newest " natural " Http://www.ebiotrade.com/newsf/2008-3/2008311174528.htm2007 of analytic and principal new mechanism year published article LiangFeng* , hanchiYan* , zhuoruWu* , niengYan, zheWang, philipD.Jeffrey, andYigongShi(2007)StructureofaSite-2ProteaseFamilyIntramembraneMetalloprotease.Science318, 1608-12(Thesingleasteriskindicatesequalcontributions. 1608-12(Thesingleasteriskindicatesequalcontributions.. NiengYan, andYigongShi(2007)Allostericactivationofabacterialstresssensor.Cell131, 441-3(Preview)GuozhouChen, philipD.Jeffrey, clayFuqua, yigongShi, andLinglingChen(2007)Structuralbasisforantiactivationinbacterialquorumsensing.PNAS104, 16474-9. [Epub2007Oct5](***)YuChen* , yanhuiXu* , qingBao, yongnaXing, zhuLi, zhengLin, jeffryBStock, philipDJeffrey, &YigongShi(2007)Structuralandbiochemicalinsightsintotheregulationofproteinphosphatase2ABysmalltantigenofSV40.Nat.Struct. &Mol.Biol.14, 527-34. [Epub2007May27](Thesingleasteriskindicatesequalcontributions. [Epub2007May27](Thesingleasteriskindicatesequalcontributions.. AdamOberstein, philipDJeffrey, andYigongShi(2007)CrystalstructureoftheBcl-XL-Beclin1peptidecomplex:BEclin1isanovelBH3-onlyprotein.J.Biol.Chem.282, 13123-32. [Epub2007Mar2]AislynD.Wist, stefanJ.Riedl, yigongShi, andGeorgeL.McLendon(2007)Structure – ActivitybasedstudyoftheSmac-bindingpocketwithintheBIR3domainofXIAP.BioorgMedChem.5, 2935-43. [Epub2007Feb11](***)QingBao, wenyuLu, joshuaD.Rabinowitz, andYigongShi(2007)CalciumblocksformationofapoptosomebypreventingnucleotideexchangeinApaf-1.MolecularCell25, 181-192QingBaoandYigongShi(2007)Apoptosome:aPlatformfortheactivationofinitiatorcaspases.CellDeathDiffer.14, 56-65. [Epub2006, sep15](CommissionedReview)(Http://www.ebiotrade.com/ )
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