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PlatinumHeavyMetalCompoundsCancerChemotherapyMolecularMechanismsClinicalCancerDrugDiscovePlatinumandOtherHeavyMetalCompoundsinCancerChemotherapy:MolecularMechanismsandClinicalApplications(CancerDrugDiscoveryandDevelopment)
by:AndreaBonetti,RobertoLeone,FrancoMuggia,StephenB.Howell
ByAndreaBonetti,RobertoLeone,FrancoMuggia,StephenB.HowellPublisher:HumanaPress
NumberOfPages:390
PublicationDate:2008-12-18
ISBN-10/ASIN:1603274588
ISBN-13/EAN:9781603274586
ProductDescription:
FollowingtheserendipitousdiscoveryofcisplatinbyBarnettRosenbergbackin1965anditsapprovalin1978bytheFoodandDrugAdministration,agrowingnumberofplatinumcompoundshaveemergedasfundamentalcomponentsforthetreatmentofdifferenttypesofcancer.Althoughreplacedbythebettertoleratedanaloguecarboplatin,cisplatinitselfisstillanimportanttoolforthetreatmentofgermcelltumorsandcancersofheadandneck.TheintroductionintotheclinicoftheDACHplatinumcompoundoxaliplatinhasbroadenedthespectrumofactivityoftheplatinumstogastro-intestinalcancers,andespeciallycolorectalcancer.Amongtheneweranaloguesonthewaytotheclinic,satraplatinisparticularlyinterestingsinceitisthefirstorallyavailableplatinumanalogue.Thepurposeofthisbookistocoverthemostimportantissuesrelatedtoplatinumdrugsincludingthemechanismsofactionandresistance;thedevelopmentofnovelplatinumcompoundsandothermetalcoordinationcompounds;thecombinationofplatinumdrugswithtargetedtherapiesforthetreatmentofcommonmalignanciessuchasbreast,colorectal,lungandgynaecologiccancers;newtherapeuticindicationsinprostateandgenitourinarytumours;integrationwithradiotherapy;specialtherapiessuchasintraperitonealadministration;pharmacodynamic-baseddosing;managementofanaemiaandmyelosuppression;mechanismsofneurotoxicityanditsprotection.
